Chirality is a phenomenon with widespread relevance in fundamental physics, material science, chemistry, optics, and spectroscopy. In this work, we show that a free electron can be converted by the…
A rich introduction captures some but not all the remarkable river has to offer
New atmospheric particles form when the stratosphere intrudes into the troposphere
Inhibition of a mutated metabolic enzyme puts the sting back in antitumor immunity
The relentless march of a highly pathogenic avian influenza virus (HPAIV) strain, known as H5N1, to become an unprecedented panzootic continues unchecked. The leap of H5N1 clade 2.3.4.4b from Eurasia…
Our Policy Forum argues that differences in structure and content mean that Indigenous knowledge must retain its integrity as a separate, parallel knowledge system. Analogous to philosophy, Indigenous knowledge should…
A. Black and J. M. Tylianakis (“Teach Indigenous knowledge alongside science,” Policy Forum, 9 February, p. 592) give an overly rosy picture of New Zealand’s policy of “mana ōrite,” or…
“New type of fossil” found in 52,000-year-old carcass
Ancient DNA study gives a Neanderthal-eye view of prehistory, offers clues to how our cousins vanished
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TnpB nucleases represent the evolutionary precursors to CRISPR-Cas12 and are widespread in all domains of life. IS605-family TnpB homologs function as programmable RNA-guided homing endonucleases in bacteria, driving transposon maintenance…
Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A…
Direct observation is central to our understanding of adaptation, but evolution is rarely documented in a large, multicellular organism for more than a few generations. In this study, we observed…
Although it is well known that the ancestors of modern humans and Neanderthals admixed, the effects of gene flow on the Neanderthal genome are not well understood. We develop methods…